西亚试剂：Several recent studies suggest that peptide or lipid nanotu

Several recent studies suggest that peptide or lipid nanotubes can penetrate through cell membranes because of their cylindrical shape and high aspect ratio and lead to cell death.24,25 Owing to similarities in geometry, functionalized SWNTs were also able to penetrate cell membranes.26 Interestingly, results from molecular dynamics simulations can be used to explain the higher antimicrobial activity of smaller-diameter nanotubes such as SWNTs in comparison to that of larger-diameter nanotubes.10,27 In this study, we postulate that SWNT aggregates caused irrecoverable damage to the E. coli bacteria by physical damage to the outer membrane of the cells, causing the release of intracellular content.

In summary, our study provides the first direct confirmation that pristine SWNTs can exhibit strong antimicrobial activity. By using highly purified, pristine SWNTs with a narrow diameter distribution, we demonstrate that direct cell contact with SWNTs can cause severe membrane damage and subsequent cell inactivation. Our finding suggests that SWNTs can be useful as building blocks for antimicrobial materials.

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