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西亚试剂：MicroRNA control of Nodal signalling

MicroRNA control of Nodal signalling

Graziano Martello1, Luca Zacchigna1, Masafumi Inui1, Marco Montagner1, Maddalena Adorno1, Anant Mamidi1, Leonardo Morsut1, Sandra Soligo1, Uyen Tran2, Sirio Dupont1, Michelangelo Cordenonsi1, Oliver Wessely2 & Stefano Piccolo1

  1. Department of Histology, Microbiology and Medical Biotechnologies, Section of Histology and Embryology, University of Padua, viale Colombo 3, 35126 Padua, Italy
  2. Departments of Cell Biology & Anatomy and Genetics, LSU Health Sciences Center, 1901 Perdido Street, New Orleans, Louisiana 70112, USA

Correspondence to: Stefano Piccolo1 Correspondence and requests for materials should be addressed to S.P. (Email: piccolo@bio.unipd.it).

MicroRNAs are crucial modulators of gene expression, yet their involvement as effectors of growth factor signalling is largely unknown. Ligands of the transforming growth factor-beta superfamily are essential for development and adult tissue homeostasis. In early Xenopus embryos, signalling by the transforming growth factor-beta ligand Nodal is crucial for the dorsal induction of the Spemann's organizer. Here we report that Xenopus laevis microRNAs miR-15 and miR-16 restrict the size of the organizer by targeting the Nodal type II receptor Acvr2a. Endogenous miR-15 and miR-16 are ventrally enriched as they are negatively regulated by the dorsal Wnt/beta-catenin pathway. These findings exemplify the relevance of microRNAs as regulators of early embryonic patterning acting at the crossroads of fundamental signalling cascades.