西亚试剂：The Flightless I Homolog, fli-1, Regulates Anterior/Posteri

The Flightless I Homolog, fli-1, Regulates Anterior/Posterior Polarity, Asymmetric Cell Division and Ovulation During Caenorhabditis elegans Development

Hansong Deng*, ${dagger}$ , Dan Xia*, ${dagger}$ , Bin Fang ${dagger}$ and Hong Zhang ${dagger}$ ,1

* Graduate Program, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100730, People's Republic of China and ${dagger}$ National Institute of Biological Sciences, Beijing 102206, People's Republic of China

1 Corresponding author: National Institute of Biological Sciences, 7 Science Park Rd., Zhongguancun Life Science Park, Beijing 102206, People's Republic of China.
E-mail: Flightless I (Fli I) is an evolutionarily conserved member of the gelsolin family, containing actin-binding and severing activity in vitro. The physiological function of Fli I during animal development remains largely undefined. In this study, we reveal a key role of the Caenorhabditis elegans Fli I homolog, fli-1, in specifying asymmetric cell division and in establishing anterior–posterior polarity in the zygote. The fli-1 gene also regulates the cytokinesis of somatic cells and the development of germline and interacts with the phosphoinositol-signaling pathway in the regulation of ovulation. The fli-1 reporter gene shows that the localization of FLI-1 coincides with actin-rich regions and that the actin cytoskeleton is impaired in many tissues in the fli-1 mutants. Furthermore, the function of fli-1 in C. elegans can be functionally substituted by the Drosophila Fli I. Our studies demonstrate that fli-1 plays an important role in regulating the actin-dependent events during C. elegans development.

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