西亚试剂优势供应上万种化学试剂产品，欢迎各位新老客户咨询、选购！
中国
联系我们

登录

￥0.00

联系方式：400-990-3999 / 邮箱：sales@xiyashiji.com

西亚试剂 —— 品质可靠，值得信赖

西亚试剂：Novel MicroRNA Candidates and miRNA-mRNA Pairs in Embryonic

PLoS ONE 3(7): e2548. doi:10.1371/journal.pone.0002548 , Gu P, Reid JG, Gao X, Shaw CA, Creighton C, et al.

Novel MicroRNA Candidates and miRNA-mRNA Pairs in Embryonic Stem (ES) Cells

Peili Gu5,12#, Jeffrey G. Reid2,6,10#, Xiaolian Gao1,2, Chad A. Shaw7, Chad Creighton9, Peter L. Tran1, Xiaochuan Zhou11, Rafal B. Drabek1,6, David L. Steffen7,8, David M. Hoang1, Michelle K. Weiss1, Arash O. Naghavi1, Jad El-daye1, Mahjabeen F. Khan1, Glen B. Legge1, David A. Wheeler6, Richard A. Gibbs6, Jonathan N. Miller3,6#, Austin J. Cooney5#, Preethi H. Gunaratne1,4,6*

1 Department of Biology & Biochemistry, University of Houston, Houston, Texas, United States of America2 Department of Chemistry, University of Houston, Houston, Texas, United States of America3 Department of Biochemistry & Molecular Biology, Baylor College of Medicine, Houston, Texas, United States of America4 Department of Pathology, Baylor College of Medicine, Houston, Texas, United States of America5 Department of Molecular & Cellular Biology, Baylor College of Medicine, Houston, Texas, United States of America6 Department of Human Genome Sequencing Center, Baylor College of Medicine, Houston, Texas, United States of America7 Department of Molecular & Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America8 Bioinformatics Research Center, Baylor College of Medicine, Houston, Texas, United States of America9 Duncan Cancer Center, Baylor College of Medicine, Houston, Texas, United States of America10 W. M. Keck Center for Interdisciplinary Bioscience Training, Houston, Texas, United States of America11 LC Sciences, Houston, Texas, United States of America12 Department of Cancer Genetics, M.D. Anderson Cancer Center, University of Texas , Houston, Texas, United States of America

Abstract

Background

MicroRNAs (miRNAs: a class of short non-coding RNAs) are emerging as important agents of post transcriptional gene regulation and integral components of gene networks. MiRNAs have been strongly linked to stem cells, which have a remarkable dual role in development. They can either continuously replenish themselves (self-renewal), or differentiate into cells that execute a limited number of specific actions (pluripotence).