西亚试剂：Single base–resolution methylome of the silkworm reveals a

Single base–resolution methylome of the silkworm reveals a sparse epigenomic map
Hui Xiang,Jingde Zhu,Quan Chen,Fangyin Dai,Xin Li,Muwang Li,Hongyu Zhang,Guojie Zhang,Dong Li,Yang Dong,Li Zhao,Ying Lin,Daojun Cheng,Jian Yu,Jinfeng Sun,Xiaoyu Zhou,Kelong Ma,Yinghua He,Yangxing Zhao,Shicheng Guo,Mingzhi Ye,Guangwu Guo,Yingrui Li,Ruiqiang Li,Xiuqing Zhang,Lijia Ma,Karsten Kristiansen,Qiuhong Guo,
Jianhao Jiang,Stephan Beck,Qingyou Xia,Wen Wang& Jun Wang et al.

 regulation in insects may have effects on diverse biological processes. Here we survey the methylome of a model insect, the silkworm Bombyx mori, at single-base resolution using Illumina high-throughput bisulfite sequencing (MethylC-Seq). We conservatively estimate that 0.11% of genomic cytosines are methylcytosines, all of which probably occur in CG dinucleotides. CG methylation is substantially enriched in gene bodies and is positively correlated with gene expression levels, suggesting it has a positive role in gene transcription. We find that transposable elements, promoters and ribosomal DNAs are hypomethylated, but in contrast, genomic loci matching small RNAs in gene bodies are densely methylated. This work contributes to our understanding of epigenetics in insects, and in contrast to previous studies of the highly methylated genomes of Arabidopsis1 and human2, demonstrates a strategy for sequencing the epigenomes of organisms such as insects that have low levels of methylation.

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