西亚试剂：Genome-wide association studies identify IL23R-IL12RB2 and

Genome-wide association studies identify IL23R-IL12RB2 and IL10 as Beh?et's disease susceptibility loci
Nobuhisa Mizuki1,13, Akira Meguro1,13, Masao Ota2, Shigeaki Ohno3, Tomoko Shiota1, Tatsukata Kawagoe1, Norihiko Ito1, Jiro Kera1, Eiichi Okada4, Keisuke Yatsu5, Yeong-Wook Song6, Eun-Bong Lee6, Nobuyoshi Kitaichi7, Kenichi Namba8, Yukihiro Horie8, Mitsuhiro Takeno9, Sunao Sugita10, Manabu Mochizuki10, Seiamak Bahram11,12, Yoshiaki Ishigatsubo9 & Hidetoshi Inoko5

Beh?et's disease is a chronic systemic inflammatory disorder characterized by four major manifestations: recurrent ocular symptoms, oral and genital ulcers and skin lesions1. We conducted a genome-wide association study in a Japanese cohort including 612 individuals with Beh?et's disease and 740 unaffected individuals (controls). We identified two suggestive associations on chromosomes 1p31.3 (IL23R-IL12RB2, rs12119179, P = 2.7 × 10?8) and 1q32.1 (IL10, rs1554286, P = 8.0 × 10?8). A meta-analysis of these two loci with results from additional Turkish and Korean cohorts showed genome-wide significant associations (rs1495965 in IL23R-IL12RB2, P = 1.9 × 10?11, odds ratio = 1.35; rs1800871 in IL10, P = 1.0 × 10?14, odds ratio = 1.45).

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