西亚试剂：Chiral Lewis Base Catalyzed Highly Enantioselective Reducti

Chiral Lewis Base Catalyzed Highly Enantioselective Reduction of N-Alkyl β-Enamino Esters with Trichlorosilane and Water

Xinjun Wu1,2, Yang Li1, Chao Wang1, Li Zhou1, Prof.?Dr. Xiaoxia Lu1, Prof.?Dr. Jian Sun1

Keywords:amino esters;asymmetric reduction;enantioselectivity;organocatalysis;trichlorosilane

First, test the water! In the presence of a chiral Lewis base catalyst 2, the supposedly moisture-unfriendly reduction system with trichlorosilane was found to be highly efficient and enantioselective when using water as an additive. For the first time, this method enables the reduction of a broad range of N-alkyl β-enamino esters 1 to give N-alkyl β-amino esters 3 in good to high yields and with excellent enantioselectivities (see scheme).