西亚试剂 ：Repression of Intestinal Stem Cell Function and Tumorigen

Disturbing the homeostasis of the stem cell pool can go two ways--it can either reduce intestinal epithelial cell regeneration or increase the proliferation of stem cells," said Diaz-Meco. "Cancer is produced by the accumulation of mutations in critical genes that control central mechanisms of cell growth. Stem cells are a 'permanent' population in the intestine and a reservoir for those mutations. Therefore, if stem cell activity is increased, as in the case of intestines deficient in PKC-zeta, then the likelihood of developing tumors is much higher, and when the tumor is initiated it becomes more aggressive.以上资料由西亚试剂：http://www.xiyashiji.com/提供