西亚试剂：对变构作用认识的变化

Hesam N. Motlagh, James O. Wrabl, Jing Li & Vincent J. Hilser

Allostery is the process by which biological macromolecules (mostly proteins) transmit the effect of binding at one site to another, often distal, functional site, allowing for regulation of activity. Recent experimental observations demonstrating that allostery can be facilitated by dynamic and intrinsically disordered proteins have resulted in a new paradigm for understanding allosteric mechanisms, which focuses on the conformational ensemble and the statistical nature of the interactions responsible for the transmission of information. Analysis of allosteric ensembles reveals a rich spectrum of regulatory strategies, as well as a fra-mework to unify the descr-ption of allosteric mechanisms from different systems.

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