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Until just a short time ago, the boundaries of biology were set by nature. But those limits are receding. In the past decade, the field of synthetic biology has shattered the idea that living cells must stick to the biomolecular widgets that have evolved naturally. Synthetic biology — a more complex form of genetic engineering — allows researchers to assemble molecular gears on an entirely new scale. From such tools, biological freedom has emerged; even the rule that DNA's alphabet consists of just four letters has been thrown out of the window.
In this special issue, Nature surveys the messy landscape of synthetic biology and the various scientific tribes that are pushing it forward. Although the field is young, it is already divided into factions that foresee different futures.
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