西亚试剂：Rb suppresses human cone-precursor-derived retinoblastoma t

Rb suppresses human cone-precursor-derived retinoblastoma tumours

Xiaoliang L. Xu, Hardeep P. Singh, Lu Wang, Dong-Lai Qi, Bradford K. Poulos, David H. Abramson, Suresh C. Jhanwar & David Cobrinik

Retinoblastoma is a childhood retinal tumour that initiates in response to biallelic RB1 inactivation and loss of functional retinoblastoma (Rb) protein. Although Rb has diverse tumour-suppressor functions and is inactivated in many cancers1, 2, 3, 4, 5, germline RB1 mutations predispose to retinoblastoma far more strongly than to other malignancies6. This tropism suggests that retinal cell-type-specific circuitry sensitizes to Rb loss, yet the nature of the circuitry and the cell type in which it operates have been unclear7, 8.（doi: 10.1038/nature13813 & doi: 10.1038/nature13748）

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