西亚试剂：Parent stem cells can serve as niches for their daughter ce

Stem cells integrate inputs from multiple sources. Stem cell niches provide signals that promote stem cell maintenance1, 2, while differentiated daughter cells are known to provide feedback signals to regulate stem cell replication and differentiation3, 4, 5, 6. Recently, stem cells have been shown to regulate themselves using an autocrine mechanism7. The existence of a ‘stem cell niche’ was first postulated by Schofield in 1978 to define local environments necessary for the maintenance of haematopoietic stem cells1. Since then, an increasing body of work has focused on defining stem cell niches1, 2, 3, 4, 5, 6. Yet little is known about how progenitor cell and differentiated cell numbers and proportions are maintained. In the airway epithelium, basal cells function as stem/progenitor cells that can both self-renew and produce differentiated secretory cells and ciliated cells8, 9. Secretory cells also act as transit-amplifying cells that eventually differentiate into post-mitotic ciliated cells9, 10

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