西亚试剂：：Histone Acetyltransferase Regulates Active DNA

Weiqiang Qian1,2,*, Daisuke Miki1,*, Heng Zhang1,2, Yunhua Liu2,3, Xi Zhang4, Kai Tang2, Yunchao Kan5, Honggui La1,2, Xiaojie Li6, Shaofang Li7, Xiaohong Zhu2, Xiaobing Shi4, Kangling Zhang8, Olga Pontes9, Xuemei Chen7, Renyi Liu7, Zhizhong Gong6, Jian-Kang Zhu1,2,†

Active DNA demethylation is an important part of epigenetic regulation in plants and animals. How active DNA demethylation is regulated and its relationship with histone modification patterns are unclear. Here, we report the discovery of IDM1, a regulator of DNA demethylation in Arabidopsis. IDM1 is required for preventing DNA hypermethylation of highly homologous multicopy genes and other repetitive sequences that are normally targeted for active DNA demethylation by Repressor of Silencing 1 and related 5-methylcytosine DNA glycosylases. IDM1 binds methylated DNA at chromatin sites lacking histone H3K4 di- or trimethylation and acetylates H3 to create a chromatin environment permissible for 5-methylcytosine DNA glycosylases to function. Our study reveals how some genes are indicated by multiple epigenetic marks for active DNA demethylation and protection from silencing.