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HACH DIPHENYLCARBAZONE REAGENT
| Flammability | 1 | |
| Toxicity | 2 | |
| Body Contact | 0 | |
| Reactivity | 1 | |
| Chronic | 2 | |
| SCALE: Min/Nil=0 Low=1 Moderate=2 High=3 Extreme=4 | ||
Reagent for determination of chloride.
"ingredients for chloride reagent solution", "chlorine determination", M00015
Accidental ingestion of the material may be damaging to the health of the individual. The toxicity of phthalates is not excessive due to slow oral absorption and metabolism. Absorption is affected by fat in the diet. Repeated doses can cause cumulative toxic effects, and symptoms include an enlarged liver which often reverses if exposure is maintained. Carbohydrate metabolism is disrupted, and cholesterol and triglyceride levels in the blood falls. There can also be withering of the testicles. Some phthalates can increase the effects of antibiotics, thiamine (vitamin B1) and sulfonamides.
Although the material is not thought to be an irritant, direct contact with the eye may cause transient discomfort characterized by tearing or conjunctival redness (as with windburn). Slight abrasive damage may also result. The material may produce foreign body irritation in certain individuals.
The material is not thought to produce adverse health effects or skin irritation following contact (as classified using animal models). Nevertheless, good hygiene practice requires that exposure be kept to a minimum and that suitable gloves be used in an occupational setting. Entry into the blood-stream, through, for example, cuts, abrasions or lesions, may produce systemic injury with harmful effects. Examine the skin prior to the use of the material and ensure that any external damage is suitably protected.
The material is not thought to produce either adverse health effects or irritation of the respiratory tract following inhalation (as classified using animal models). Nevertheless, adverse effects have been produced following exposure of animals by at least one other route and good hygiene practice requires that exposure be kept to a minimum and that suitable control measures be used in an occupational setting.
The material may produce peroxisome proliferation. Peroxisomes are single, membrane limited, cytoplasmic organelles that are found in the cells of animals, plants, fungi and protozoa. Peroxisome proliferators include certain hypolipidaemic drugs, phthalate ester plasticisers, industrial solvents, herbicides, food flavours, leukotriene D4 antagonists and hormones. Numerous studies in rats and mice have demonstrated the hepatocarcinogenic effects of peroxisome proliferators, and these compounds have been unequivocally established as carcinogens. However it is generally conceded that compounds inducing proliferation in rats and mice have little, if any, effect on human liver except at very high doses or extreme conditions of exposure. Long term exposure to high dust concentrations may cause changes in lung function i.e. pneumoconiosis; caused by particles less than 0.5 micron penetrating and remaining in the lung. Prime symptom is breathlessness; lung shadows show on X-ray. Limited evidence suggests that repeated or long-term occupational exposure may produce cumulative health effects involving organs or biochemical systems. There has been some concern that this material can cause cancer or mutations but there is not enough data to make an assessment. Exposure to phthalates over years leads to pain, numbness and spasms in the hands and feet. Many people have developed multiple disorders in the nervous system and the balancing system. Levels of sex hormones are reduced in women, leading to missed ovulations and miscarriages. They also reduce sperm counts and fertility in men. They mimic certain sex hormones and can damage the fetus. Phthalates are found in paints, inks and glues.
