VALPROIC ACID MSDS报告

化学品及企业标识

PRODUCT NAME

VALPROIC ACID

NFPA

PRODUCT USE

Anticonvulsant; antiepileptic. Used in the treatment of various forms of epilepsy
including petit mal and in infantile spasms. Given as the acid or sodium salt. The action
of valproic acid may involve a modification of the behaviour of gamma- aminobutyric acid
(GABA) in the brain.

SYNONYMS

C8-H16-O2, (CH3CH2CH2)2CHCO2H, "acetic acid, dipropyl-", "acetic acid, 2-propyl-",
"acetic acid, 2-propyl-", "dipropylacetic acid", "di-n-propylacetic acid", "di-n-
propylacetic acid", "n-dipropylacetic acid", "n-dipropylacetic acid", n-DPA, n-DPA, "2-
propylpentanoic acid", "2-propylpentanoic acid", "2-propylvaleric acid", "2-propylvaleric
acid", "Abbott 44090", Depakene, Depakine, Epilim, Valproate, "anticonvulsant/
antiepileptic"

CANADIAN WHMIS SYMBOLS

EMERGENCY OVERVIEW

RISK

Harmful if swallowed.

POTENTIAL HEALTH EFFECTS

ACUTE HEALTH EFFECTS

SWALLOWED

  Accidental ingestion of the material may be harmful; animal experiments indicate that ingestion of less than 150 gram may be fatal or may produce serious damage to the health of the individual.  Ingestion of low-molecular organic acid solutions may produce spontaneous hemorrhaging, production of blood clots, gastrointestinal damage and narrowing of the esophagus and stomach entry.  

EYE

  There is some evidence to suggest that this material can causeeye irritation and damage in some persons.  Solutions of low-molecular weight organic acids cause pain and injuryto the eyes.  

SKIN

  Skin contact is not thought to produce harmful health effects (as classified using animal models). Systemic harm, however, has been identified following exposure of animals by at least one other route and the material may still produce health damage following entry through wounds, lesions or abrasions. Good hygiene practice requires that exposure be kept to a minimum and that suitable gloves be used in an occupational setting.  Entry into the blood-stream, through, for example, cuts, abrasions or lesions, may produce systemic injury with harmful effects. Examine the skin prior to the use of the material and ensure that any external damage is suitably protected.  

INHALED

  Inhalation of aerosols (mists, fumes), generated by the material during the course of normal handling, may be damaging to the health of the individual.  The material is not thought to produce respiratory irritation (as classified using animal models). Nevertheless inhalation of vapors, fumes or aerosols, especially for prolonged periods, may produce respiratory discomfort and occasionally, distress.  

CHRONIC HEALTH EFFECTS

  There is some evidence that human exposure to the material may result in developmental toxicity. This evidence is based on animal studies where effects have been observed in the absence of marked maternal toxicity, or at around the same dose levels as other toxic effects but which are not secondary non-specific consequences of the other toxic effects.  Exposure to the material for prolonged periods may cause physical defects in the developing embryo (teratogenesis).  Several off-spring of eight pregnant women taking valproate as an  antiepileptic drug were deformed -  two babies had facial abnormalities  and one baby had a heart lesion.  When given by gavage to rats, 600 mg/kg was maternally toxic and produced  100% embryonic resorption. At 400 mg/kg 52% of all embryos were resorbed  and 49% of survivors were malformed. Defects included ectrodactyly,  hydronephrosis, cardiovascular defects, hypoplastic bladder, rib and  vertebral defects. At 200 mg/kg, defects included hydronephrosis,  cardiovascular abnormalities and rib defects (primarily wave ribs).  

成分及组成信息

危险性质描述

急救措施

消防措施

泄露应急处理

处理和储存

接触控制

理化特性

稳定性和反应活性

毒理学信息

生态学资料

废弃处理

运输信息

法规信息

其他信息