7-氨基放线菌素D(7-AAD)

属性
敏感性
对光和湿度敏感
熔点
252-253 °C
溶解性
Soluble in DMSO (20 mg/ml), ethanol, chloroform (1 mg/ml), and dichloromethane (20 mg/ml).
存贮条件
储存温度 2-8°C
描述
产品介绍
7-Aminoactinomycin D ，an analog of the antibiotic actinomycin D ，is a fluorescent DNA dye which is useful for quantifying apoptosis. 7-AAD has also been used in studies on cellular necrosis, chromosome analysis and in cell cycle studies. As a fluorescent DNA dye, 7-AAD is able to intercalate DNA via binding to the GC regions. When used in flow cytometery, 7-AAD can be used to discriminate between live cells as well as early and late apoptosis. Additionally, 7-AAD can also be combined with other staining procedures for analysis of intracellular and cell surface antigens enabling multiparametric analysis. When utilizing 7-AAD with flow cytometery, early and late apoptosis can be studied by varying the concentration of 7-AAD. During apoptosis, the cellular plasma membrane is altered progressively, which allows the cell membrane to become permeable to 7-AAD. 7-AAD staining can also be adapted to include staining with other dyes for intracellular and cell surface antigens. 7-Aminoactinomycin D is an inhibitor of DNA Polymerase and RNA Polymerase
别名
7-AAD; 7-AminoActinomycin D;7-AAD
应用
A fluorescent DNA dye for apoptosis and flow cytomtery studies. -----------------------
密度 ：1.4±0.1 g/cm³

沸点 ：1400.8±65.0 ℃ at 760 mmHg

分子式 ：C62H87N13O16

分子量 ：1270.432

闪点 ：801.0±34.3 ℃

精确质量 ：1269.639404

PSA ：386.00000

LogP ：-5.02

外观性状 ：红色至暗紫色粉末

蒸汽压 ：0.0±0.3 mmHg at 25℃

折射率 ：1.664

计算化学 ：

1.疏水参数计算参考值（XlogP）:3.1

2.氢键供体数量:6

3.氢键受体数量:19

4.可旋转化学键数量:8

5.互变异构体数量:1000

6.拓扑分子极性表面积382

7.重原子数量:91

8.表面电荷:0

9.复杂度:3070

10.同位素原子数量:0

11.确定原子立构中心数量:0

12.不确定原子立构中心数量:10

13.确定化学键立构中心数量:0

14.不确定化学键立构中心数量:0

15.共价键单元数量:1

-----------------------
符号 ：GHS06

信号词 ： Danger

危害声明 ：H300

警示性声明 ：Missing Phrase - N15.00950417

个人防护装备 ： Eyeshields; Faceshields; full-face particle respirator type N100 (US); Gloves; respirator cartridge type N100 (US); type P1 (EN143) respirator filter; type P3 (EN 143) respirator cartridges

危害码 (欧洲) ：T+: Very toxic;

风险声明 (欧洲) ：R26/27/28; R36/37/38

安全声明 (欧洲) ：26-28-36/37-45

危险品运输编码 ：UN 3462 6

WGK德国 ：3

RTECS号 ：AU1579000

包装等级 ：II

危险类别 ：6.1(a)