化学性质
属性
存贮条件
储存温度 2-8°C
描述
产品介绍
Butyrl Cholinesterase catalyzes the hydrolysis of a number of choline esters according to the following reaction:Acylcholine H2O → choline acidIt is a tetrameric glycoprotein with four subunits of equal size, each having a molecular weight of 110 kDa. Butyryl cholinesterase hydrolyzes butyrylcholine four times more rapidly than acetylcholine. Unlike acetyl cholinesterase, it does not hydrolyze D-≥-methyl acetylcholine. It is inhibited by 10-5 M physostigmine, numerous organophosphate esters, the carbamate derivates and quaternary ammonium salts.
别名
BChE;Choline esterase,butyryl;Acylcholine acyl-hydrolase;Pseudocholinesterase;Cholinesterase,Butyryl from Horse Serum
生化机理
Butyrylcholinesterase (BChE) is a serine hydrolase that is structurally similar to acetylcholinesterase (AChE), but differs in substrate specificities and inhibitor sensitivities. BChE can, unlike AChE, efficiently hydrolyze larger esters of choline such as butyrylcholine and benzoylcholine. The enzyme is a tetrameric glycoprotein with four equal subunits (110 kDa each). The enzyme is activated by Ca2 and Mg2 and the activity is constant over the pH range 6.0-8.0. It is inhibited by Betaine, nicotine, organophosphates, carbamates.
备注
A lyophilized powder.
应用
Selective inhibition of BChE activity can be used in the detection of organophosphates.Its use in the treatment of organophosphate toxicity has been explored. It has been reported that the level of BChE in human blood correlates to the degree of protection against potentially toxic nerve agents.Cholinesterases have also been investigated for their role in Alzheimer’s disease.
危险属性
个人防护设备
Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
WGK德国
3
