化学性质
属性
溶解性
DMSO
存贮条件
储存温度-20°C
描述
生化机理
MK-0591 is a selective and specific 5-Lipoxygenase-activating protein (FLAP) inhibitor. MK-0591 is a synthetic compound which specifically inhibits the activity of 5-Lox and is currently under development for the treatment of asthma. Research of involvement of 5-lipoxygenase activating protein in the amyloidotic phenotype of an Alzheimer's disease mouse model showed that a novel functional role for 5-lipoxygenase activating protein in the pathogenesis of Alzheimer's disease-like amyloidosis, and suggest that its pharmacological inhibition could provide a novel therapeutic opportunity for Alzheimer's disease. Another research showed 5-Lipoxygenase-activating protein (FLAP) inhibitor MK-0591 prevents aberrant alveolarization in newborn mice exposed to 85% oxygen in a dose- and time-dependent manner.
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密度 :1.2±0.1 g/cm³
沸点 :751.3±60.0 ℃ at 760 mmHg
分子式 :C34H35ClN₂O₃S
分子量 :587.171
闪点 :408.2±32.9 ℃
精确质量 :586.205688
PSA :89.65000
LogP :8.31
蒸汽压 :0.0±2.6 mmHg at 25℃
折射率 :1.617