4-[(3-溴苯基)氨基]-6,7-二甲氧基喹啉

别名：N-(3-溴苯基)-6,7-二甲氧基喹唑啉-4-胺;4-[(3-溴苯基)氨基]-6,7-二甲氧基喹啉产品编号：264136 CAS号：153436-54-5 分子式：C₁₆H₁₄BrN₃O₂ 分子量：360.21

相似产品

订货信息

订货编号	产品名称	规格	包装	价格
A58589-10mg	4-[(3-溴苯基)氨基]-6,7-二甲氧基喹啉	≥98.0%	10mg	315.00
A58589-50mg	4-[(3-溴苯基)氨基]-6,7-二甲氧基喹啉	≥98.0%	50mg	496.00
A58589-250mg	4-[(3-溴苯基)氨基]-6,7-二甲氧基喹啉	≥98.0%	250mg	1458.00

化学性质

属性
溶解性
Soluble in DMSO (5 mg/ml).
存贮条件
储存温度-20°C
描述
产品介绍
PD153035(ZM 252868; AG 1517)是高活性EGFR选择性抑制剂，Ki和IC50分别为5.2 pM和29 pM，而对PGDFR，FGFR，CSF-1，InsR和Src活性极低。
别名
4-[(3-溴苯基)氨基]-6,7-二甲氧基喹唑啉;ZM 252868; AG 1517; SU 5271; PD-153035;ZM 252868; AG 1517; Tyrphostin AG 1517; SU 5271; PD153035; PD-153035; 4-[(3-Bromophenyl)amino]-6,7-dimethoxyquinazoline
生化机理
PD 153035 is an extremely potent and specific inhibitor of the tyrosine kinase activity of the EGFR (epidermal growth factor receptor; IC50 = 25 pM; Kι = 6 pM). PD 153035 rapidly suppresses auto-phosphorylation of EGFR at low nanomolar concentrations in fibroblasts or in human epidermoid carcinoma cells. PD 153035 also selectively blocks EGF-mediated cellular processes including mitogenesis, early gene expression, and oncogenic transformation.
应用
An extremely potent and specific inhibitor of EGFR tyrosine kinase activity. -----------------------

密度：1.499g/cm3
沸点：472.1ºC at 760 mmHg
闪点：239.3ºC
折射率：1.679 蒸汽压：4.38E-09mmHg at 25°C

最新产品