硝酸舍他康唑

属性
熔点
163-165 °C
溶解性
Soluble in DMSO (20 mg/ml), and methanol.
存贮条件
储存温度-20°C
描述
产品介绍
Sertaconazole nitrate是一种外用广谱抗真菌药，是用来治疗表面皮肤和粘膜感染的辅助用药.
别名
硝酸舍他康唑; 1-(2-((7-氯苯并(b)噻吩-3-基)甲氧基)-2-(2,4-二氯苯基)乙基)-1H-咪唑硝酸盐;1-[2-[(7-Chlorobenzo[b]thien-3-yl)methoxy]-2-(2,4-dichlorophenyl)ethyl]-1H-imidazole nitrate;Ertaczo; Dermofix; Konzert; FI7056
生化机理
Sertaconazole interacts with 14-alpha demethylase, a cytochrome P-450 enzyme necessary to convert lanosterol to ergosterol. As ergosterol is an essential component of the fungal cell membrane, inhibition of its synthesis results in increased cellular permeability causing leakage of cellular contents. Sertaconazole may also inhibit endogenous respiration, interact with membrane phospholipids, inhibit the transformation of yeasts to mycelial forms, inhibit purine uptake, and impair triglyceride and/or phospholipid biosynthesis
备注
Sertaconazole nitrate is a topical broad-spectrum antifungal that is developed to provide an additional agent for the treatment of superficial cutaneous and mucosal infections. -----------------------
沸点 ：614.1ºC at 760mmHg

分子式 ：C20H16Cl₃N₃O4S

分子量 ：500.783

闪点 ：325.2ºC

精确质量 ：498.992706

PSA ：121.34000

LogP ：7.19160

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危险品运输编码 ：NONH for all modes of transport

海关编码 ：2934999090