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6-(5H)-菲啶酮

别名:6(5H)-苯并萘酮 产品编号:252152 CAS号:1015-89-0 分子式:C13H9NO 分子量:195.22

订货信息

订货编号 产品名称 规格 包装 价格 数量 操作
A55013-1g 6-(5H)-菲啶酮 ≥98.0%(HPLC) 1g 90.00

A55013-5g 6-(5H)-菲啶酮 ≥98.0%(HPLC) 5g 251.00

A55013-25g 6-(5H)-菲啶酮 ≥98.0%(HPLC) 25g 1023.00

化学性质


属性熔点

290-292 °C(lit.)

储存条件

2-8°C






描述





产品介绍


6(5H)-Phenanthridinone is a small molecule poly(ADP-ribose) polymerase (PARP) inhibitor with immunosupperessive effects. 6(5H)-Phenanthridinone has been shown to inhibit concanavilin A-induced lymphocyte proliferation, producing the observed immunosuppressant activity of this compound. It has also been shown to potentiate the effect of ionizing radiation on developing cells, strongly increasing the radiation-induced inhibition of cell proliferation, which suggests use of 6(5H)-Phenanthridinone as a probe into the role of PARP in cellular response to irradiation. Treatment of cells with 6(5H)-Phenanthridinone and various DNA-damaging agents showed a resistance to apoptosis versus treatment with DNA-damaging agents alone, indicating that PARP activity is involved in the apoptotic process.




别名


6(5H)-5-氮杂菲酮;6(5H)-菲啶酮;6(5H)-Phenanthridinone;5,6-Dihydrophenanthridin-6-one;NSC 11021;NSC 40943;NSC 61083




应用


Reactant involved in:Synthesis of 5,6-dihydrophenanthridine sulfonamides. Oxidative coupling with diphenylacetylene. Direct copper acetate-catalyzed N-cyclopropylation of cyclic amides.Reactant involved in the synthesis and/or pharmacological activity of biologically active molecules including: Potassium channel KV1.3 and IK-1 inhibitors. HIV-1 integrase inhibitors.



危险属性




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