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LDN-57444-西亚试剂有售,LDN-57444分子式,LDN-57444价格,西亚试剂有各种化学试剂,生物试剂,分析试剂,材料试剂,高端化学,耗材,实验室试剂,科研试剂,色谱耗材www.xiyashiji.com

LDN-57444

别名:LDN-57444 产品编号:252032 CAS号:668467-91-2 分子式:C17H11Cl3N2O3 分子量:397.64

订货信息

订货编号 产品名称 规格 包装 价格 数量 操作
A54954-5mg LDN-57444 ≥98.0% (HPLC) 5mg 335.00

A54954-25mg LDN-57444 ≥98.0% (HPLC) 25mg 1234.00

A54954-100mg LDN-57444 ≥98.0% (HPLC) 100mg 4304.00

化学性质


属性
溶解性
Soluble in DMSO (20 mg/ml).
存贮条件
储存温度2-8°C
描述
产品介绍
LDN-57444是一种可逆的竞争性的蛋白酶体抑制剂,,抑制UCch-L1时,IC50为0.88 μM,比作用于亚型Uch-L3选择性高30倍。
别名
LDN 57444;LDN 57444; 5-Chloro-1-[(2,5-dichlorophenyl)methyl]-1H-indole-2,3-dione 3-(O-acetyloxime)
生化机理
UCH-L1 Inhibitor is an isatin O-acyl oxime compound reported to act as a potent, reversible, competitive, and active site-directed inhibitor of UCH-L1 with greater selectivity over UCH-L3. Additionally, UCH-L1 Inhibitor has been shown to increase proliferation of UCH-L1 expressing tumor cell line SH-SY5Y. Potentially useful for studying the roles of UCH-L1 in cancer, Parkinson’s disease, and other neurological disorders. Permeability may vary from cell type to cell type.
应用
A potent, reversible, active site-directed UCH-L1 inhibitor

危险属性


标识符号 GHS09

信号词
Warning
警示性声明 P273-P501

危害声明 H410

WGK德国
3

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