化学性质
属性溶解性Soluble in water (9 mg/ml), and 1 M NH4OH (50 mg/ml).描述产品介绍D-AP5 is a selective antagonist of the NMDA receptor. D(-)-2-Amino-5-phosphonovaleric acid is described to antagonize amino acid-induced synaptic excitations, blocking L-aspartate and dorsal root-evoked spinal neuron excitation, without affecting cholinergic excitation induced by exogenous acetylcholine administration. Evoked electrical activity of neurons is suppressed by D(-)-2-Amino-5-phosphonovaleric acid antagonism of motoneuronal depolarizations at the NMDAR. The (+)-stereoisomer of D(-)-2-Amino-5-phosphonovaleric acid demonstrates considerably diminished NMDAR activity as compared to this (-)-isomer.别名D-AP5;D-AP5;D(-)-APV;D-2-Amino-5-phosphonovaleric acid;(2R)-2-ammonio-5-phosphonatopentanoate;D(-)-2-Amino-5-phosphonopentanoic acid;5-Phosphono-D-norvaline生化机理Anticonvulsant; potent and selective N-methyl-D-aspartate (NMDA) receptor antagonist; active enantiomer of 2-amino-5-phosphonopentanoic acid.应用A selective antagonist of the NMDA receptor.-----------------------
储存条件Store at RT
危险属性
标识符号
GHS07 信号词Warning警示性声明P261-P305 + P351 + P338 危害声明H315-H319-H335 个人防护设备dust mask type N95 (US), Eyeshields, GlovesWGK德国3-----------------------
危险品标志 :Xi
危险类别码 :36/37/38
安全说明 :26-36WGK Germany3