S-(4-硝基苄基)-6-硫肌苷

属性熔点

187-190 °C(lit.)

密度

1.3904 (rough estimate)

折射率

1.6460 (estimate)

储存条件

2-8°C

溶解度

0.1 M HCl: slightly soluble

形态

solid

颜色

white





溶解性


Soluble in water (Partly miscible), DMSO, methanol, and DMF. Insoluble in hexane.




存贮条件


储存温度2-8°C





描述





产品介绍


S-(4-Nitrobenzyl)-6-thioinosine (NBTI, NBMPR) is a small molecule inhibitor of equilibrative nucleoside transporter (ENT) proteins. These transport proteins are described in relation to their sensitivity to NBMPR, designated as either es (NBMPR-sensitive) or ei (NBMPR-insensitive). They provide good research tools anticancer, antiviral, cardioprotective, and neuroprotective agents. Inhibition of ENT1 by NBMPR blocks the uptake and transport of adenosine, which affects the regulation of extracellular adenosine levels and the cardiac system signaling associated with adenosine.




别名


NBMPR;NBTI;6-[(4-硝基苄基)硫代]-9-β-D-呋喃核糖基嘌呤;NBMPR;NBTI




应用


An inhibitor of ENTs with potential anticancer, cardio-, and neuro- protective properties