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L-环丝氨酸

别名:D-4-异唑基酮 产品编号:251114 CAS号:339-72-0 分子式:C3H6N2O2 分子量:102.09

订货信息

订货编号 产品名称 规格 包装 价格 数量 操作
A54528-25g L-环丝氨酸 ≥97.0% 25g 1995.00

A54528-100g L-环丝氨酸 ≥97.0% 100g 6654.00

化学性质


属性





折光率


1.48




密度


1.2800




熔点


146°C




溶解性


Soluble in water (25 mg/ml).




存贮条件


储存温度-20°C





描述





产品介绍


L-Cycloserine is an irreversible inhibitor of 3-ketodihydrosphingosine synthetase, which is the first enzyme of the sphingolipid pathway, and causes the synthesis of sphingolipids to decrease. In vitro studies demonstrated that L-cyloserine inhibits 3-ketodihydrosphingosine synthetase 100 times more than D-Cycloserine .Research regarding L-Cycloserine and its effect on the immune response suggest that L-Cycloserine increases the level of IL-4 producing helper T cells and suppress the adhesion molecules CD29 and CD98. L-Cycloserine also inhibits SPTLC (serine palmitoyltransferase (SPT)), and HIV-1 investigations in the CD4+ lymphoid cell line (CEM) have shown that L-Cycloserine can inhibit HIV-1 replication.




别名


;(S)-4-Amino-3-isoxazolidone




生化机理


Blocks sphingosine biosynthesis by inhibition of ketosphinganine synthetase. Cytotoxicity toward neuroblastoma and medulloblastoma cells mediated by suppression of ganglioside synthesis.




应用


An irreversible inhibitor of 3-ketodihydrosphingosine synthetase



危险属性




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