化学性质
属性熔点
252-253℃
比旋光度
D28 +125° (c = 1.30 in CHCl3)
密度
1.28
闪点
226℃
储存条件
Desiccate at -20°C
溶解性
Soluble in ethanol, and DMSO
存贮条件
储存温度2-8℃
描述
产品介绍
Withaferin A, a steroidal lactone originally purified from Withania somnifera, has been shown to have potent antiangiogenesis activity in vivo as well as potent growth inhibitory activities. This compound binds to Vimentin, the intermediate filament (IF) protein, and causes Vimentin filaments to aggregate in vitro. Furthermore, experiments have demonstrated that Withaferin-induced inhibition of capillary growth in a mouse model of corneal neovascularization was compromised in Vimentin-deficient mice. Additional experiments have reported Withaferin A to be a proteasome inhibitor, with a specific primary target for 20S proteasome β5 subunit. Withaferin A demonstrates the potential to inhibit NFκB activation by prevention of tumor necrosis factor-activated IκB kinase β via a thioalkylation-sensitive redox mechanism. In other studies, Withaferin A was also observed to alter cytoskeletal architecture by covalently binding Annexin II and stimulating its basal F-actin cross-linking activity. Another characteristic of Withaferin A that has been noted is it's ability to induce regeneration of axons and dendrites and also reconstruct pre and postsynapses in neurons of mice.
别名
;5,6-Epoxy-4,27-dihydroxy-1-oxowitha-2,24-dienolide; Withaferine A
生化机理
Steroidal lactone that exhibits cytotoxicity towards tumor cells. Protective effects attributed to anti-lipid peroxidative, antioxidant and detoxifying functionality.
应用
An antiangiogenesis compound and poteasome inhibitor. -----------------------
密度 ：1.3±0.1 g/cm³
沸点 ：680.7±55.0 ℃ at 760 mmHg
熔点 ：252-253ºC
分子式 ：C28H38O6
分子量 ：470.598
闪点 ：226.7±25.0 ℃
精确质量 ：470.266846
PSA ：96.36000
LogP ：3.80
蒸汽压 ：0.0±4.8 mmHg at 25℃
折射率 ：1.599
危险属性
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危险品运输编码 ：NONH for all modes of transport
