化学性质
属性储存条件
2-8°C
酸度系数(pKa)
3.5(at 25℃)
Merck
13,2476
敏感性
对光线敏感
溶解性
Soluble in water (Partly miscible), ethanol, and phenol.
存贮条件
储存温度-20°C
描述红色针状结晶或结晶性粉末,无臭,无味,有吸湿性。Mp>300℃, mp210-220℃(色深),比旋光度[α]23656-59°(水),在361nm波长处有最大吸收。溶于水(1:80)、乙醇(1:180)和醋酸,不溶于氯仿、乙醚和丙酮。LD50(大鼠,腹腔)1364 mg/kg。
别名
腺苷钴胺; 腺甙钴胺; 5,6-二甲基苯并咪唑基-5'-脱氧腺嘌呤核苷基钴胺;5′-Deoxyadenosylcobalamine;Adenosyl cobalamine;Cobamamide;DMBC coenzyme
生化机理
Vitamin B12 (cobalamin) refers to a group of chemically-related cobalt containing molecules involved in cell processes such as DNA synthesis, fatty acid synthesis, energy production and regulation. The physiologically active forms of vitamin B12 include methylcobalamin and adenosylcobalamin, whereas hydroxocobalamin (vitamin B12a, OHCbl) and cyanocobalamin (CNCbl) are storage and delivery forms. Bacteria-derived hydroxocobalamin (OHCbl) and CNCbl are converted in humans to useful coenzyme forms to support metabolic processes such as mitochondrial methylmalonylcoenzyme A mutase conversion of methylmalonic acid (MMA) to succinate to link lipid and carbohydrate metabolism, and activation of methionine synthase, the rate limiting step in the synthesis of methionine. -----------------------
分子式 :C72H100CoN18O17P
分子量 :1579.582
精确质量 :1578.658325
PSA :583.18000
LogP :6.19200
危险属性
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个人防护装备 : Eyeshields; Gloves; type N95 (US); type P1 (EN143) respirator filter
危害码 (欧洲) :Xi
风险声明 (欧洲) :R36/37/38
安全声明 (欧洲) :S22-S24/25
危险品运输编码 :NONH for all modes of transport
RTECS号 :GG3800000
海关编码 :2936260000