中文名称:法尼醇
中文同义词:3,7,11-三甲基-2,6,10-十二烷三烯-1-醇,合金欢醇;金合欢醇(混合反式,96%);法呢醇,异构体混合物;法呢醇/金合欢醇(异构体混合物);菌绿烯醇;金合欢醇、里哪醇、法呢醇;法呢醇;合金欢醇
英文名称:FARNESOL
英文同义词:6,10-Dodecatrien-1-ol,3,7,11-trimethyl-2;farnesol,mixtureofisomers;Farnesylalcohol;10-dodecatrien-1-ol,3,7,11-trimethyl-6;2,6,10-trimethyl-2,6,10-dodecatrien-12-ol[qr];3,7,11-trimethyl-2,6,10-dodecatrien-1-ol[qr];3,7,11-Trimethyl-2,6,10-dodecatrienol;farnesylalcohol
CAS号:4602-84-0
分子式:C15H26O
分子量:222.37
EINECS号:225-004-1
法尼醇性质
熔点25°C
沸点149°C4mmHg(lit.)
密度0.886g/mLat20°C(lit.)
FEMA2478|FARNESOL
折射率n20/D1.490(lit.)
闪点205°F
储存条件2-8°C
酸度系数(pKa)14.69±0.10(Predicted)
形态Liquid
颜色Clearcolorlesstofaintyellow
水溶解性Notmiscibleordifficulttomixinwater.
敏感性LightSensitive
Merck14,3937
JECFANumber1230
BRN1763926
稳定性Stable.Combustible.Incompatiblewithstrongoxidizingagents.
生物活性
Farnesol是一种天然的倍半萜烯醇，有效地治疗抗代谢障碍、具有抗炎、抗氧化、抗肿瘤和抗菌活性。
靶点
Human Endogenous Metabolite
体外研究
Farnesol is a sesquiterpene alcohol that modulates cell-to-cell communication in Candida albicans . It is also shown that this molecule presents inhibitory effects against non-albicans Candida species , Paracoccidioides brasiliensis and bacteria. The minimum inhibitory concentrations (MICs) are determined in accordance with the M27-A3 protocol as described and Farnesol is tested at a concentration range of 0.29-150 μM. It is observed that Farnesol presents an inhibitory activity against C. neoformans and C. gattii (MIC range: 0.29-75.0 μM). Although Farnesol does not significantly alter phospholipase activity, a tendency to decrease this activity is observed.
化学性质
无色至微黄色油状液体。呈淡的白柠檬似香味。沸点263℃。Iml溶于3 mL 70%乙醇，溶于丙二醇和油类，不溶于水。 天然品存在于桂皮、依兰、玫瑰草、麝葵籽等中。
